Premier League fans will be delighted to wave goodbye to international football and see the English top flight back in action this weekend.
However, a host of friendlies and the inaugural UEFA Nations League have taken their toll on teams with a number of players sustaining injuries.
Luke Shaw suffered a sickening collision in England’s 2-1 defeat to Spain, with the Manchester United ace left with concussion and a serious doubt to face Watford.
Meanwhile, Lucas Torreira picked up a worrying calf injury playing for Uruguay but there is positive news for Arsenal fans – so who is available and who is sidelined for the next round of Premier League fixtures?
Lucas Torreira picked up a calf injury and was substituted at half-time as a precaution during Uruguay’s 3-1 win over Mexico last Friday.
The 23-year-old has been pictured at Arsenal’s training ground this week and could feature against Newcastle, although Alex Iwobi is a doubt due to illness.
Laurent Kosicelny is continuing his recovery from an Achilles injury while Sead Kolasinac (knee), Ainsley Maitland-Niles (broken leg) and Carl Jenkinson (ankle) are also out.
Ryan Fraser picked a knock away on international duty and is a doubt for this weekend’s clash with Leicester.
Meanwhile, Junior Stanislas, Marc Pugh and Charlie Daniels could all return against the Foxes
Brighton & Hove Albion
Pascal Gross is carrying an ankle injury but should be available to play against Southampton, while Jose Izquierdo and Florin Andone are also near a return.
Luke Shaw suffered concussion after a sickening clash during England’s defeat to Spain
Lucas Torreira suffered a calf injury on international duty with Uruguay
Stephen Ward has been struggling with a knock all season and withdrew from the Republic of Ireland’s squad with a foot injury.
Ben Gibson is also struggling with an abdominal problem while Robbie Brady has a thigh injury and Nick Pope, Steven Defour and Johann Berg Gudmundson are all out.
Josh Murphy is carrying a knock but could return against Chelsea while Aron Gunnarsson skipped international duty to focus on his recovery from a knee injury and could also play.
However, Nathaniel Mendez-Laing is still out.
Cesc Fabregas should be available following knee problems, although he may not start with Jorginho and N’Golo Kante in such good form.
Christian Benteke is being assessed after suffering a knee injury, but Wilfried Zaha should be back after a groin problem sidelined him last time out.
James Tomkins, Pape Souare and Scott Dann are all on the treatment table but Connor Wickham could feature against Huddersfield.
Christian Benteke is a doubt for Crystal Palace’s meeting with Huddersfield
Seamus Coleman suffered a stress fracture in his foot while on Republic of Ireland duty
Everton have a major injury crisis with Seamus Coleman and Dominic Calvert-Lewin the latest players to pick up injuries.
Coleman suffered a stress fracture in his foot while on Republic of Ireland duty and Calvert-Lewin was forced off during England U21’s clash with Latvia.
James McCarthy (calf), Michael Keane (head), Phil Jagielka (knee) and Andre Gomes (thigh) are all out while Richarlison is suspended.
However, Theo Walcott (abdominal), Bernard (muscle), Idrissa Gueye (knee) and Yerry Mina (ankle) could all be available for selection.
Tom Cairney (ankle), Floyd Ayite (fitness) and Tim Ream (thigh) are all in with a chance of playing against Manchester City.
Ben Hamer and Ramadan Sobhi are recovering from knocks while Jonathan Hogg is suspended.
No new injuries during the international break.
Adam Lallana picked up an injury during England training and withdrew from the squad
Simon Mignolet picked up a wrist injury while Adam Lallana pulled out of the England squad with a groin problem but both could be back for this weekend.
Alex Oxlade-Chamberlain (knee) is still out but Dejan Lovren is nearing a return.
Raheem Sterling left the England squad with a back injury but should be fit for Fulham while Danilo is also back after an ankle problem.
Bernardo Silva is a doubt after being withdrawn against Croatia while Kevin De Bruyne (knee) is still sidelined and Claudio Bravo (calf) and Eliaquim Managala (knee) are not available.
Luke Shaw suffered concussion during England’s defeat to Spain and must follow ‘return to play’ protocol before featuring again.
The minimum time out is just six days (depending on the injury), but Shaw is still unlikely to feature against Watford.
Marouane Fellaini withdrew from the Belgium squad with a small back injury but could feature while Marcos Rojo is also in contention.
Phil Jones is sidelined while Marcus Rashford is suspended.
Matt Ritchie (knee), Jonjo Shelvey (thigh) and Javi Manquillo (ankle) could all return for Rafael Benitez’s side, but Florian Lejeune is a long-term absentee.
Shane Long missed the international break with a knock but could be back on Monday night while Jan Bednarek (ankle) will not feature.
Dele Alli withdrew from the England squad but has claimed he will be fit to face Liverpool.
Hugo Lloris, Erik Lamela and Moussa Sissoko could also return.
Dele Alli pulled out of the England squad but should be fit to play Liverpool on Saturday
No new injuries during the international break, but Tom Cleverly (calf), Younes Kaboul (ankle) and Gerard Deulofeu (groin) are all out.
West Ham United
Winston Reid (knee), Andy Carroll (ankle), Arthur Masuaku (muscle) and Manuel Lanzini (knee) will not play against Everton.
Wolves have no new problems, while Ivan Cavaleiro could make his return from a back injury when Burnley visit Molineux.